Melasma is a skin condition presenting as brown patches on the face
of adults. Skin aging caused by systematic sun exposure and facial
blemishes due to excessive pigmentation are more and more common
problems today. Dark blemishes, especially on the hands and face,
are one of the greatest aesthetic concerns of modern men and women.
It is only possible to remove these skin blemishes, recover the
smoothness of the skin, and bring back its luminosity, with a
treatment that has a direct effect on the formation process of the
melanin pigment.
What is Melanin?
The particular color of the skin of each human being depends on a
dark pigment called melanin. The quantity of this pigment determines
the shade of the skin color. Melanin is produced in some cells of
the epidermis, known melanocytes. These cells possess a special
structure on the inside of their cytoplasm, called melanosome, where
the melanin is formed, following successive metabolic
transformations.
The main function of melanin is to protect us against the radiation
of the sun by filtering the harmful ultraviolet rays. Broadly
speaking, we can state that it is in geographic areas where the sun
irradiation is greater (the tropics) where we can find the ethnic
groups with the darkest skins (Africans and Amerindians). The
geographic pigmentation decreases as we approach the milder areas.
Partially, more melanised individuals can be seen in the extreme
Polar regions or areas with large extensions of snow (Eskimo or
Tibetan groups).
When we expose ourselves to intense sun, our defense mechanisms
start up against the aggression and they activate the formation of
melanin. Our body "manufactures a protective canvas" to filter the
harmful sunrays. We call the final result of this process "suntan."
Pigmentary Alterations
Apart from the density and global distribution of melanin, there are
localized concentrations of the pigment in the skin that are given
different names:
Freckles: Hyperpigmentations that are generally pale, with a
variable color, which do not grow and are innocuous. They are due to an
increased local synthesis of melanin in the epidermis. There appears to be a
genetic predisposition in their development. They predominate in exposed skin
areas, in people with fair or red hair, and they are stimulated by exposure to
the sun.
Lentigines: This is the name given to larger and darker freckles.
They are normally associated with age.
Melasmas: These are multiple, smooth, brownish-gray or blackish
pigmentary blemishes, which are badly delimitated and normally can be found on
the face, cheek and forehead. They often appear at times of hormone changes,
such as menopause, in endocrine illnesses, due to the use contraceptives, in old
age and during pregnancies. The typical blemish shaped like a butterfly that
appears on the face of pregnant women is given the special name of cloasma or
gravida melasma.
Cosmelan
The Cosmelan depigmentation program is a versatile and adaptable
treatment for the elimination of melasmic blemishes.
Action of Mechanism
The Cosmelan program's action is based on the inhibition of
tyrosinase, a basic enzyme in the melanin formation process. Several
of the substances present in Cosmelan act by blocking this enzyme,
or by inverting the metabolic process of the transformation chain.
Properties
Cosmelan causes a rapid depigmenting action, without peeling, with a
high safety margin. It can be started any time of the year, is very
efficient in treating all types of melasma, and is compatible with
any type of skin phototype.
What to expect with treatment
One week after starting the treatment a noticeable improvement of
the skin will be seen. In addition, the skin has a rejuvenated
appearance. In 99% of the cases of hyperpigmentation, the blemish
disappearance process reaches 95%. The initial treatment is done in
the office with subsequent applications at home. Follow-up visits
are needed to ascertain progress and make adjustments as needed.